Detection and Drug Sensitivity of Enterobacteriaceae Producing Extended Spectrum β-lactamases in Respiratory Tract Infection

Objective:To detect production of enterobacteriaceae producing extended spectrum β-lactamases(ESBLs) in respiratory tract infection and drug–resistance to 10 kinds of antibacterial drugs.Method: Disc confirmatory test was used to detect ESBLs in 326 strains of enterobacteriaceae;Kirby—Bauer agar diffusion method was used to judge drug sensitivity.Result: In this sample,productive rate of ESBLs was 33.4%,and productive rate of ESBLs in Klebsiella pneumonia and escherichia coli was 37.1% and 35.6%.The ESBLs-producing strains had very high drug-resistance rate for the all antibiotics except for imipenem.The resistant rates of cefoperazone/sulbactam to ESBLs-Producing strains were the lower.Conclusion: The prevalence of ESBLs in isolates of enterobacteriaceae in respiratory tract infection;it is necessary for clinical laboratory to detect ESBLs in isolates of enterobacteriaceae routinely.Imipenem was the effective antibiotics to infections caused by ESBLs-producing strains.