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2021•Blood Cancer JournalOpen access

Iron deficiency in JAK2 exon12 and JAK2-V617F mutated polycythemia vera

Dan Liu, Zefeng Xu, Peihong Zhang, Tiejun Qin, Bing Li, Shiqiang Qu, Lijuan Pan, Wenyu Cai, Jinqin Liu, Huijun Wang, Qi Sun, Xiujuan Sun, Meng Jiao, Qingyan Gao, Zhongxun Shi, Huijun Huang, Gang Huang, Robert Peter Gale, Zhijian Xiao

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Abstract

Somatic driver mutations in JAK2 ( JAK2 V617F and exon 12 mutations) are detected >95% of persons with polycythemia vera (PV) [ 1 , 2 , 3 , 4 ]. Iron deficiency is universal in persons with PV at diagnosis and can be worsened by phlebotomy [ 5 ]. Precise mechanisms of iron deficiency in persons with PV at diagnosis are unknown. A previous study reported heterogeneous bone marrow expression of erythroferrone (ERFE) and hepcidin, important regulators of iron metabolism, in mice with JAK2 V617F or JAK2 exon12 mutation [ 6 ].

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What this paper is about

Somatic driver mutations in JAK2 ( JAK2 V617F and exon 12 mutations) are detected >95% of persons with polycythemia vera (PV) [ 1 , 2 , 3 , 4 ]. Iron deficiency is universal in persons with PV at diagnosis and can be worsened by phlebotomy [ 5 ]. Precise mechanisms of iron deficiency in persons with PV at diagnosis are unknown. A previous study reported heterogeneous bone marrow expression of erythroferrone (ERFE) and hepcidin, important regulators of iron metabolism, in mice with JAK2 V617F or JAK2 exon12 mutation [ 6 ].

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Available abstract

Somatic driver mutations in JAK2 ( JAK2 V617F and exon 12 mutations) are detected >95% of persons with polycythemia vera (PV) [ 1 , 2 , 3 , 4 ]. Iron deficiency is universal in persons with PV at diagnosis and can be worsened by phlebotomy [ 5 ]. Precise mechanisms of iron deficiency in persons with PV at diagnosis are unknown. A previous study reported heterogeneous bone marrow expression of erythroferrone (ERFE) and hepcidin, important regulators of iron metabolism, in mice with JAK2 V617F or JAK2 exon12 mutation [ 6 ].

Key concepts: Polycythemia vera, JAK2 V617F, Medicine, Myeloproliferative Disorders, Hematology, Iron deficiency, Internal medicine, Janus kinase 2

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