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2014•Practical medicineRequires access

Выявление мутации Jak2 V617F при хронических Ph-негативных заболеваниях

А. М. Саврилова, А. В. Костерина, А. Р. Ахмадеев

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Abstract

Chronic myeloproliferative diseases (CMPD) are clonal disorders with excess proliferation (cell production) of one or more lineages of hematopoiesis. The most common CMPDs are polycythemia vera, essential thrombocytosis and idiopathic primary myelofibrosis. Specific molecular abnormalities were found that are characteristic for these disorders. The most common of them is mutation of gene Janus kinase 2 (Jak2 V617F).

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What this paper is about

Chronic myeloproliferative diseases (CMPD) are clonal disorders with excess proliferation (cell production) of one or more lineages of hematopoiesis. The most common CMPDs are polycythemia vera, essential thrombocytosis and idiopathic primary myelofibrosis. Specific molecular abnormalities were found that are characteristic for these disorders. The most common of them is mutation of gene Janus kinase 2 (Jak2 V617F).

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Available abstract

Chronic myeloproliferative diseases (CMPD) are clonal disorders with excess proliferation (cell production) of one or more lineages of hematopoiesis. The most common CMPDs are polycythemia vera, essential thrombocytosis and idiopathic primary myelofibrosis. Specific molecular abnormalities were found that are characteristic for these disorders. The most common of them is mutation of gene Janus kinase 2 (Jak2 V617F).

Key concepts: JAK2 V617F, Polycythemia vera, Thrombocytosis, Janus kinase 2, Myelofibrosis, Myeloproliferative Disorders, Mutation, Haematopoiesis

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Выявление мутации Jak2 V617F при хронических Ph-негативных заболеваниях — Research Paper | ScholarLens