Efficacy of Citalopram Combined with Low-dose Amitriptyline and Paroxetine in the Treatment of Depression

Objective To study value and safety of the citalopram combined with low-dose amitriptyline and paroxetine in the treatment of depression.Methods Collecting from January 2009 to October 2009 in our hospital out-patient and hospitalization in patients with depression,112 cases were randomly divided into combined low dose of citalopram paroxetine amitriptyline group and 56 cases of two groups,treatment for 6 weeks using Hamilton Depression Rating Scale(HAMD) and adverse reactions Scale(TESS) in the treatment of pre-and post assessment of 1,2,4,6 weekend efficacy and adverse reactions of drugs.Results Citalopram combined with low-dose amitriptyline and paroxetine in the treatment groups 1 ～ 2 weeks before and after the HAMD score difference was significan(tP0.05),treatment for 4 ～ 6 weeks,no significant difference between the two groups(P0.05),citalopram combined group of low-dose amitriptyline in the overall incidence of adverse reactions 26.79%,paroxetine,compared with 46.43%,difference between two groups was statistically significan(tP0.05).Conclusion Citalopram combined with low-dose amitriptyline and paroxetine in the treatment of depression are effective and less adverse reactions,but combined with low-dose of citalopram amitriptyline more secure,taking convenient,less adverse reactions,can be used as treatment of depression drug of choice.