Efficacy of Citalopram Combined with Low-dose Amitriptyline and Paroxetine in the Treatment of Depression

Objective To study value and safety of the citalopram combined with low-dose amitriptyline and parosetine in the treatment of depression.Methode Collecting form January 2009 to October 2009in our hospotal out-patient and hospitalization in patients with depression,112 cases were randomly divided into combined low dose of citalopram parosetine amitriptyline group and 56 cases were rand groups,treatment for 6 weeks using hamilton Depression Rating Scale (HAMD)and adverse reactions Scale (TESS)in the treatment of pre-and post assessment of 1,2,4,6weekend efficacy and adverse reactions of drugs.Results Citalopram combined with low-dose amitriptyline and paroxetine in the treatment groups 1~2weeks befor and aftet the HAMD score difference was significant (P 0.05),citalopram combined with 46.43%,differenct between two groups was statistically significant(P<0.05).Conclusion Citalopram combined with low-dose amitripty but combined with low -Dose of citalopram amitriptylion drutg of choice. Key words: Depression; Citalopram combined with low-dose amitriptyline; paroxetine