Research on sedation,hypnosis,hangover response,and tolerance of Fructus Cnidii

Objective To study the efficacy,tolerance and hangover response of sedation and hypnosis of ethanol extract of Fructus Cnidii on mice.Methods Crude drug and ethanol of Fructus Cnidii were studied the effects on autonomic activities,and dose,latent period and duration of hypnosis sleep induced by sodium pentobarbital injection.The ethanol extracts were also studies the autonomic activities after sleep.The effects of repeated-dose on autonomic avtivities and hypnosis were also studied.Results Compared with the blank control group,the times of autonomic activities in groups of crude drug,65% ethanol extract and 95% ethanol extract were significantly lower,and the sleep time in the groups of crude drug and ethanol extract was much longer.The frequencies of pre-sleep standing in diazepam group and 65% ethanol extract were significantly lower.The times of activities after sleep in the two ethanol extract groups were obviously more,and the times of standing on 1,3,5,15 day after administration of crude drug,ethanol extracts were obviously less.The sleep time in experimental groups increased with the time after Fructus Cnidii administration,while decreased with diazepam administration.Fructus Cnidii ethanol extracts did not show drug tolerance,while diazepam did.Conclusion Fructus Cnidii has a significant sedative and hypnotic effects on mice,and the hangover response and tolerance are less than diazepam.