Study of hypnotic effects of the vegetable oil extract of Fructus schisandrae Chinensis on mice

Objective To investigate the hypnotic effects of vegetable oil extract of Fructus schisandrae Chinensis.Methods vegetable oil extraction extracted of Fructus schisandrae Chinensis.Healthy ICR mice were randomly divided into blank control,high,middle and low dose groups.The effect of sleep improvement was studied by the experiments of sleep-induced directly,prolonging sleeping time induced by pentobarbital sodium,affecting mice sleeping rate under the threshold hypnogenesis dosage of pentobarbital sodium and affecting sleeping delitescence induced by tobarbital sodium.The control group given intragastric administration of olive oil 20 ml/kg/d and the high,middle and low dose were given extracts 600 mg/kg/d for 15 d.Results Oil extraction had no direct effect on the sleep of the mice;could significantly prolong the time of sleep induced by pentobarbital sodium,and increased the number of sleeping mice induced by subthreshold dose of pentobarbital sodium.Conclusion Oil extract of Fructus schisandraeChinensis with the new technique could improve the sleep function of mice.