Investigation on the condition of the neonatal HBV infection in 511 HBV-positive pregnant women in Nanning

Objective To investigate the condition of the neonatal HBV infection in hepatitis B virus(HBV)-positive pregnant women.Methods Among 511 hepatitis B surface antigen(HBsAg)-positive pregnant women,191 women with HBsAg,HBeAg,anti-HBc were divided into great three positive group,320 women with HBsAg,anti-HBe,anti-HBc were divided into small three positive group.And their newborns born within 24 h after birth were tested out five indicators of hepatitis B.Results In great three positive group 92 neonates were infected by HBV,the infection rate was 48.17%;In small three positive group 12 neonates were infected by HBV,the infection rate was 3.75%;The difference between two groups had statistical significance P0.01.Conclusion The great three positive in pregnant women are risk factors of neonatal HBV infection,It should be necessary to strengthen the blocking of the HBV intrauterine infection of HBV-positive pregnant women,In order to reduce the occurrence of HBV infection in newborns.