Effect of finasteride on microvascular density in BPH patients with large-volume prostate

Objective To evaluate preoperative finasteride on decreasing operative bleeding during TURP with prostate size greater than 80 mL,and to study its mechanism.Methods Totally 166 patients with benign prostatic hyperplasia(BPH) with prostate size greater than 80 mL were scheduled for TURP;before surgery,40 of them were received 5 mg of finasteride daily for one week(A group),45 of them were received 5 mg of finasteride for two weeks(B group),38 of them were received 5 mg of finasteride for four weeks(C group),the other 43 patients were not received finasteride(control group).A comparative study of clinical data was made among the four groups.Results The operation was successfully completed in 166 cases.Intraoperative blood loss,blood loss of 1 gram prostate tissue for resection,the expression of microvascular density in the groups A,B,control were no statistical significance difference(P0.05),whereas there were statistically significant difference between the groups C and control(P0.05).Conclusion For BPH patients with large-volume prostate,the use of finasteride before TURP for 4 weeks can reduce perioperative bleeding.