The research of Finasteride and Tamsulosin to reduce hemorrhage during TURP

Objective To discuss the clinical effect mechanism of preoperative finasteride and tamsulosin on decreasing operative bleeding during TURP with patient of benign prostatic hyperplasia. Methods During a randomized controlled trial, 96 cases of hospitalized patients which were scheduled for TURP were divided into four groups: 23 of them were received finasteride for over three months(A group), 32 of them were received finasteride for one month(B group), 20 of them were received finasteride and tamsulosin for three months(C group)and the other 21 patients have not taken any medicine for BPH(D group). To calculate bleeding volume during operation; After surgery, testing microvascular density(MVD) in prostate tissue and comparing the difference among all the groups. Results The bleeding amount has no statistically significant difference between group A and B(P0.05), but the prostate MVD was statistically significant difference(P0.05); Compared with group C, interoperative blood loss and MVD decreases obviously in group A and B, the difference was statistically significant(P0.01). Conlusion Finasteride administration for more than one month before operation can effectively decrease the blood loss during TURP.