Effect of Finasteride on microvascular density in BPH patients with large-volume prostate

【Objective】 To evaluate preoperative finasteride on decreasing operative bleeding during TURP,and to study its mechanism.【Methods】 Totally 160 patients with benign prostatic hyperplasia(BPH) were scheduled for TURP;before surgery,45 of them were received 5mg of finasteride daily for two week(A group),52 of them were received 5mg of finasteride daily for four weeks(B group),the other 63 patients were not received finasteride(control group).A comparative study of clinical data was made among the four groups.【Results】 The operation was successfully completed in 160 cases.For patients with prostate size among 40～80mL,Intraoperative blood loss,blood loss of 1 gram prostate tissue for resection,the expression of microvascular density of groups A and groups B were significantly less than the control group(P0.05);for patients with prostate size greater than 80mL,there were no statistical significant difference in the above clinical indexes between the groups A and control group(P0.05),whereas there were statistically significant difference between the groups B and control group(P0.05).【Conclusion】 For patients with prostate size among 40～80mL,the use of finasteride before TURP for 2 weeks can reduce perioperative bleeding;for patients with prostate size greater than 80mL,only the use of finasteride before TURP for 4 weeks can reduce perioperative bleeding.