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2010•Chinese Preventive MedicineRequires access

Effect of Astragalus polysaccharides on stress response ability and regulation of free radicals in mice

Liu Bin-y

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Abstract

Objective To study the effect of Astragalus polysaccharides(APS)on the stress response ability and anti-aging mechanism by evaluating blood superoxide dismutase(SOD)activity and malondialdehyde(MDA)concentration in mice.Methods Mice were randomly divided into high-dose APS,low-dose APS and control groups.The three groups of mice were challenged with experiments of swimming fatigue resistance,cold-resistance and hypoxia tolerance ability under normal air pressure,and activities of SOD as well as contents of MDA in blood serum of those mice were determined.Results Compared with the control group,APS improved cold-resistance ability by decreasing death rate,extended swimming time and hypoxia tolerance time under normal air pressure in mice(P0.05).APS also improved the activity of SOD and decreased MDA content in blood serum(P0.01).Conclusion APS has significant antioxidant and anti-aging effects in vivo in mice.

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What this paper is about

Objective To study the effect of Astragalus polysaccharides(APS)on the stress response ability and anti-aging mechanism by evaluating blood superoxide dismutase(SOD)activity and malondialdehyde(MDA)concentration in mice.Methods Mice were randomly divided into high-dose APS,low-dose APS and control groups.The three groups of mice were challenged with experiments of swimming fatigue resistance,cold-resistance and hypoxia tolerance ability under normal air pressure,and activities of SOD as well as contents of MDA in blood serum of those mice were determined.Results Compared with the control group,APS improved cold-resistance ability by decreasing death rate,extended swimming time and hypoxia tolerance time under normal air pressure in mice(P0.05).APS also improved the activity of SOD and decreased MDA content in blood serum(P0.01).Conclusion APS has significant antioxidant and anti-aging effects in vivo in mice.

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Available abstract

Objective To study the effect of Astragalus polysaccharides(APS)on the stress response ability and anti-aging mechanism by evaluating blood superoxide dismutase(SOD)activity and malondialdehyde(MDA)concentration in mice.Methods Mice were randomly divided into high-dose APS,low-dose APS and control groups.The three groups of mice were challenged with experiments of swimming fatigue resistance,cold-resistance and hypoxia tolerance ability under normal air pressure,and activities of SOD as well as contents of MDA in blood serum of those mice were determined.Results Compared with the control group,APS improved cold-resistance ability by decreasing death rate,extended swimming time and hypoxia tolerance time under normal air pressure in mice(P0.05).APS also improved the activity of SOD and decreased MDA content in blood serum(P0.01).Conclusion APS has significant antioxidant and anti-aging effects in vivo in mice.

Key concepts: Malondialdehyde, Superoxide dismutase, Astragalus, Oxidative stress, Antioxidant, Hypoxia (environmental), Polysaccharide, Pharmacology

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Effect of Astragalus polysaccharides on stress response ability and regulation of free radicals in mice — Research Paper | ScholarLens