Correlative study on blocking effect of hepatitis B immunoglobulin combined with hepatitis B vaccine on mother-infant transmission of hepatitis B virus

Objective:To explore the failure causes of mother-infant transmission of hepatitis B virus(HBV)blocked by hepatitis B immunoglobulin(HBIG)combined with hepatitis B vaccine.Methods:218 pregnant women with positive HBsAg,HBeAg and HBV-DNA were selected;the content of HBV-DNA in pregnant women before delivery,the contents of HBsAg and anti-HBs in neonates at 24 hours after birth before blocking,infants aged 7 months and one year were detected;all the neonates were injected with 200 IU HBIG into deltoid muscle and 10 μg recombinant hepatitis B vaccine into lateral muscles of anterior thighs at 24 hours after birth,200 IU HBIG were injected after two weeks,10 μg recombinant hepatitis B vaccine were injected at one and six months.Results:The positive rates of HBsAg in neonates at 7 months and one year who were born by the pregnant women with serum HBV-DNA1×106 copies/ml before delivery were 18.12% and 19.38%,respectively;while the positive rates of HBsAg in neonates at 7 months and one year who were born by the pregnant women with serum HBV-DNA1×106 copies/ml before delivery were 7.50% and 7.25%,respectively,there was significant difference between the two groups(P0.05).After injection with HBIG and hepatitis B vaccine,the positive rates of HBsAg in intrauterine infection group at 7 months and one year were 75.00% and 74.19%,respectively;the positive rates of HBsAg in non-intrauterine infection group at 7 months and one year were 3.76% and 4.19%,respectively,there was significant difference between the two groups(P0.01).Conclusion:Intrauterine infection and high content of serum HBV-DNA in pregnant women before delivery are the main failure causes of mother-infant transmission of HBV,comprehensive measures should be taken to improve the blocking effect.