The Clinical Observation on the Effect of Hepatitis B Immunoglobulin on the Interruption of Hepatitis B Virus Intrauterine Infection

Objective: To explore the effectiveness of hepatitis B immunoglobulin on interrupting hepatitis B virus intrauterine infection with passive immunization from mother to infant.Method: One hurdred cases of HbsAg positive pregnant women were randomly allocated to two groups,of 50 women were allocated to trial groups,and injected with 200 IU of hepatitis B immunoglobulin for 1 injection at the 28th,32th and 36th weeks of pregnancy respectively,50 women in the control group received no treatment.The samples of cord blood from the newborns in two groups were collected and tested for HBsAg and HBeAg by ELISA and FQ—PCR.Result : The intrauterine infection rate in HBIg group and control group were 10% and 23.7%,respectively,with significant difference(P0.05).Conclusion: HBIG can significantly decrease the HBV intrauterine infection rate when administered to pregnant women of HBsAg positive regularly during late pregnancy.