2007•Journal of clinical and experimental medicineRequires access
Clinical Observation on Effect of Hepatitis B Immunoglobulin on Interruption of Hepatitis B Virus Intrauterine Infection
Cheng Yi
Open publisher page 2 citations
Abstract
Objective To explore the effectiveness of hepatitis B immunoglobulin on interrupting hepatitis B virus intrauterine infection from mother to infant with passive immunization.Methods One hundred cases of HbsAg positive pregnant women were randomly allocated to two groups. Among them, 50 women were allocated to trial group and injected with 200 IU of hepatitis B immunoglobulin for 1 injection at 28th, 32th and 36th weeks of pregnancy respectively, and 50 women in control group received no treatment. The samples of cord blood from the newborns in two groups were collected and tested for HBsAg and HBeAg by ELISA and FQ―PCR.Results The intrauterine infection rate in HBIG group and control group were 10% and 23.7% respectively with significant statistical difference (P0.05).Conclusion HBIG can significantly decrease the rate of HBV intrauterine infection when it is regularly administered to pregnant women with positive HBsAg during late pregnancy.