2002•Journal of Shanghai MedicaRequires access

Induction of Apoptosis of Gastric Cancer SGC-7901 Cell with Liposome-Mediated c-myc Antisense Phosphorothioate Oligodeoxynucleotide

Lin Geng

Abstract

Purpose To study the effects of c myc antisense phosphorothioate oligodeoxynucleotide(APSODN) on apoptosis of gastric cancer SGC?7901 cell. Methods After gastric cancer SGC?7901 cell were treated by c myc APSODN,we studied the expression of c myc gene using Northern blot and Western blot,apoptosis using terminal uridine deoxynucleotidyl nick end labeling(TUNEL),cell cycle using flow cytometer. Results c myc APSODN could induce apoptosis of gastric cancer SGC?7901 cell,simultaneously,G0/G1 arrest,and the effect of induction was related to trearted time and density. Conclusions c myc APSODN can induce apoptosis of gactric cancer cell.

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Key concepts: Apoptosis, TUNEL assay, Molecular biology, Cell cycle, Cell, Cancer research, Cancer, Cell growth