ScholarLens Back to search
2009•Unpublished venueRequires access

Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats

Xiaoyu Xu

Open publisher page 0 citations

Abstract

Objective: To explore the effect of tetramethylpyrazine(TMP) on the expression of vascular endothelial growth factor(VEGF) in the synovium of adjuvant-induced arthritis(AIA) in rats.Method: AIA rats were treated with different doses of TMP.The effects of treatment were monitored by footpad thickness,contents of tumor necrosis factor-α(TNF-α) in serum,microvessel density(MVD) and the expression of VEGF protein in the synovium.Result: Compared with arthritis model,100 mg·kg-1 TMP could remarkably reduce the footpad thickness,contents of TNF-α in serum and the expression of VEGF in the synovium.Conclusion: TMP can attenuate the degree of chronic inflammation in AIA rats,and its mechanism might be associated with inhibiting the expression of VEGF.

About this research paper

What this paper is about

Objective: To explore the effect of tetramethylpyrazine(TMP) on the expression of vascular endothelial growth factor(VEGF) in the synovium of adjuvant-induced arthritis(AIA) in rats.Method: AIA rats were treated with different doses of TMP.The effects of treatment were monitored by footpad thickness,contents of tumor necrosis factor-α(TNF-α) in serum,microvessel density(MVD) and the expression of VEGF protein in the synovium.Result: Compared with arthritis model,100 mg·kg-1 TMP could remarkably reduce the footpad thickness,contents of TNF-α in serum and the expression of VEGF in the synovium.Conclusion: TMP can attenuate the degree of chronic inflammation in AIA rats,and its mechanism might be associated with inhibiting the expression of VEGF.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To explore the effect of tetramethylpyrazine(TMP) on the expression of vascular endothelial growth factor(VEGF) in the synovium of adjuvant-induced arthritis(AIA) in rats.Method: AIA rats were treated with different doses of TMP.The effects of treatment were monitored by footpad thickness,contents of tumor necrosis factor-α(TNF-α) in serum,microvessel density(MVD) and the expression of VEGF protein in the synovium.Result: Compared with arthritis model,100 mg·kg-1 TMP could remarkably reduce the footpad thickness,contents of TNF-α in serum and the expression of VEGF in the synovium.Conclusion: TMP can attenuate the degree of chronic inflammation in AIA rats,and its mechanism might be associated with inhibiting the expression of VEGF.

Key concepts: Tetramethylpyrazine, Vascular endothelial growth factor, Microvessel, Medicine, Arthritis, Tumor necrosis factor alpha, Inflammation, Adjuvant

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats — Research Paper | ScholarLens