Effect of Dexarmthasome of Jianlishu Powder on the Release of Tumor Necrosis Factor-α in Rats of Adjuvant-induced Arthritis Model

OBJECTIVE: To study of effects of dexarmethasome of Jianlishu Powder on the release of tumor necrosis factor-α in rats of adjuvant arthritis model. METHODS: Adjuvant-induced arthritis (AIA) was induced by injection of frenndi's complete adjuvant in rats' plantar to observe the effects of Jianlishu Powder on rice' hypersensitivity reaction, thickness of inflamed plantar of both feet, and levels of tumor necrosis factor-α(TNF-α), Interleukin-2 (IL-2) and circulating immune complex (CIC) in AIA rats. RESULTS:rats' right posterior metatarsus which was injected with adjuvant was swollen from the second day for 15 days (primary lesion). Jianlishu Powder significantly inhibited feet swelling induced by collagen dose-dependently and down-regulate the contents of TNF-α,IL-2 and CIC thus resulting in an anti-inflammatory action in AIA rats(P0.01).CONCLUSION: Jianlishu Powder possesses the ability against AIA, meanwhile, it can down-regulate proinflammatory agents and related inflammatory mediators.