2009•PubMedRequires access

[Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats].

Qiang Ma, Gang Chen, Jifen Zhang, Binbin Feng, Xiaoyu Xu

Abstract

OBJECTIVE: To explore the effect of tetramethylpyrazine (TMP) on the expression of vascular endothelial growth factor (VEGF) in the synovium of adjuvant-induced arthritis (AIA) in rats. METHOD: AIA rats were treated with different doses of TMP. The effects of treatment were monitored by footpad thickness, contents of tumor necrosis factor-alpha (TNF-alpha) in serum, microvessel density (MVD) and the expression of VEGF protein in the synovium. RESULT: Compared with arthritis model, 100 mg x kg(-1) TMP could remarkably reduce the footpad thickness, contents of TNF-alpha in serum and the expression of VEGF in the synovium. CONCLUSION: TMP can attenuate the degree of chronic inflammation in AIA rats, and its mechanism might be associated with inhibiting the expression of VEGF.

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Key concepts: Tetramethylpyrazine, Vascular endothelial growth factor, Medicine, Arthritis, Tumor necrosis factor alpha, Microvessel, VEGF receptors, Internal medicine