Study on pharmacokinetics of Norfloxacin in carp following different forms administration

Several pharmacokinetics relative datas such as absorption, distribution, elimination and bioavailability have been set up in this study on pharmacokinetics of Norfloxacin in carp following different forms administration. Following single muscular injection and oral administration, the serum concentration the data of Norfloxacin in carp were best described by a two-compartment open model for dose of 10 mg Norfloxacin /kg body weight. Following single mixed in diet oral administration, the serum concentration-time data for Norfloxacin were best described as a one-compartment open model. The main pharmacokinetics parameters by muscular injection administration: AUC 24.9481 μg·h·mL-1, Cmaxl6.8992 μg·mL- 1, t1/2α 0. 1279 h, t1/2β 3.4032 h. The main pharmacokinetics prameters by orally administration: AUC 150.6029 μg·h·mL-l, Cmax5.7998 μg·mL-l, t1/2α3.407lh, t1/2β77. 1239h. The chief pharmacokinetics parameters by mixed in diet oral administered: AUC 6.8183 μg·h·mL- l, Cmax1 .7217μg·mL- l, t1/2ka 0.22643h,t1/2ke 2.0213h. The results showed that the main parameters following different forms administration were significantly different (P 0.01).