Pharmacokinetic of Enrofloxacin in Carp Following Different Ways of Administration

The concentration of enrofloxacin in tissues of carp following enterocoelia injection administration and oral administration was evaluated by HPLC respectively.Several pharmacokinetics parameters such as absorption,distribution and elimination were set up.The results showed that the concentration of enrofloxacin in plasma ,liver,kidney and muscle of carp following two different forms of administration was described as a two-compartment model with 1st order absorption. The pharmacokinetic parameters in plasma by enterocoelia injection administration were:AUC 59.185 6 μg·h·mL-1,Ka 75.762 7 h-1,t1/2β 96.545 6 h,T(peak) 0.073 0 h,and C(max) 3.297 0 μg·mL-1;the pharmacokinetic parameters in plasma after oral administration were AUC 600.296 1 μg·h·mL-1,Ka 0.169 3 h-1,t1/2β168.287 1 h,T(peak) 3.665 5 h,and C(max) 3.266 1 μg·mL-1.These results indicated that enterocoelia injection administration led to more rapid absorption,less retaining time and higher peak concentration than oral administration.