Observation on the results of interventive treatment of impaired glucose tolerance patients with acarbose

Objective To observe the results of intervening treatment of abnormal inhibition glucose tolerance (IGT) subjects with acarbose. Methods One hundred and twenty-six IGT subjects were,according to the WHO diagnostic criterion,randomly divided into two groups,the Diet+Exercise Group (Group Ⅰ) and Acarbose Treatment Group (Group Ⅱ),each consisted of 63 subjects and followed up for one year.The subjects in Group Ⅰ were only treatment with diet plus exercise,while those in Group Ⅱ were treated with diet plus exercise and orally given acarbose.of 50mg,three times per day.The variations of fasting plasma glucose (FPG),postprandial plasma glucose (2HPG),total cholesterol(TC),total triglyceride (TG) 2 hours after oral glucose tolerance test (OGTT),insulin(PINS) two hours after fasting insulin and OGTT were determined once per three months. Results There were no differences between the two groups before the experiment and a year after the experiment FPG in Group Ⅰ increased slightly and HPG decreased and with an incidence of diabetes of 9.5%.The FPG abd HGP in Group Ⅱ markedly decreased and with an incidence of diabetes of 3.2%,showing a significant diference as compared with that of Group Ⅰ (P0.05).There were no differences in secretion of insulin between the two groups before and after treatment. Conclusion Application of acarbose in the intervening treatment of IGT subjects can reduce the incidence of diabetes and without increase the secretion of insulin.