Clinical research on Acarbose of interventive treatment of patients with impaired glucose tolerance

Objective To investigate the therapeutic efficacy of Acarbose on patients with impaired glucose tolerance.Methods While 140 cases of impaired glucose tolerance were controled diet plus exercise for 1 year,the variations of fasting plasma glucose(FPG),post prandial plasma glucose(2HPG), 2 hours after oral glucose tolerance test(OGTT),insulin(PINS)2 hours after fasting insulin and OGTT,insulin resistance levels in two groups were observed with Acarbose or placebo borandomly and double-blinded.Results There was no significant difference of the sugar tolerance between placebo group and Acarbose group in pretherapy(P0.05).An incidence of diabetes of placebo group was 8.1%;compared to placebo group,the FPG, 2 hPG,FINS and PINS, insulin resistance index were obviously decreased in two groups after treatment of Acarbose,while with an incidence of diabetes of 4.6%.Conclusion Application of Acarbose in the intervening treatment Of IGT subjects can reduce the incidence of diabetes and improve impaired glucose tolerance,while it can degrade insulin resistance.