A Comparison of Enrofloxacin, Danofloxacin, Difloxacin in the Treatment of Experimental Pasteurella multocida Infection of Chickens

The minimal inhibitory concentrations(MICs) of enrofloxacin, danofloxacin and difloxacin for Pasteurella multocida were determined by two fold dilution method in vitro . The inhibitory tests in vitro showed that the MICs of enrofloxacin, danofloxacin and difloxacin was 0.05 , 0.2 and 0.4 mg/L for Pasteurella multocida , respectively. Treatment trials on chickens with experimentally induced fowl cholera were carried out with enrofloxacin, danofloxacin and difloxacin at dosage rate of 5 mg/kg by oral administration twice daily for 3 successive days. Following the treatment with enrofloxacin, danofloxacin and difloxacin (po, 5 mg/kg) against fowl cholera for 3 days, the curative rates of the drugs for Pasteurella multocida infected chickens were 96 7%, 83 3% and 83 3%, respectively. In the Pasteurella multocida infected and untreated groups, mortality of the chickens was 100%. There were no significant difference in weight gains among the three groups given the above drugs.