Pharmacodynamical studies of danofloxacin against experimentally induced fowl cholera and complicated mycomplasmosis and colibacillosis in chickens

Pharmacodynamics of a new domestic antibacterial danofloxacin soluble powder against artificially infected with P.multocida as well as Mycoplasma gallisepticum and Escherichia coli.in chickens was studied.Every therapeutic experiment were randomly divided into three different doses of danofloxacin group,enrofloxacin group ,positive and negative control groups.Infection chickens were given respectively via the drinking water danofloxacin(high dose 100mg.L -1 ,middle dose 50mg.L -1 and low dose 25mg.L -1 ),enrofloxacin(50mg.L -1 )for a succesive 4 or 5 days when significantly clinical symptoms were observed.The results revealed that the cure rate of three dose danofloxacin and enrofloxacin group following 4 days treatment against fowl cholera were 93.3%,93.3%,80%,86.7% respectively.The mortality of the infected and untreated group was 66.7%.Following the treatment with three dose danofloxacin and enrofloxacin for 5 days,the cure rate against complicated mycoplasmosis and colibacillosis in chickens was 95%,92.5%,75%,85% respectively.At the end of experiment observation ,were positive percent of antibody response in surving birds 0,10%,40%,30% and mean air-sac lesion scores were 0.4, 0.6 ,1.2 and 1.0 mortality,positive percent of antibody response and mean air-sac lesion scores of the infected and untreated chickens were 100% and 40% respectively.