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2012•Chinese Journal of AsthmaRequires access

Role of interleukin-35 in the mechanism of bronchial asthma

Bin Li

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Abstract

Bronchial asthma (asthma) is a chronic inflammatory airway disease involved in many cytokines, the mechanism may be related with the imbalance of Th1/Th2 cells or the abnormalities of CD4+CD25+T cells, Th17/IL-17 and so on. Interleukin-35 (IL-35) is a newly discovered cytokine, which is closely related to the immune function of Th17/IL-17 and Tregs. IL-35 may be involved in the pathogenesis of asthma, which is expected to become a new target for the treatment of asthma. This review describes the relative researches on IL-35.

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What this paper is about

Bronchial asthma (asthma) is a chronic inflammatory airway disease involved in many cytokines, the mechanism may be related with the imbalance of Th1/Th2 cells or the abnormalities of CD4+CD25+T cells, Th17/IL-17 and so on. Interleukin-35 (IL-35) is a newly discovered cytokine, which is closely related to the immune function of Th17/IL-17 and Tregs. IL-35 may be involved in the pathogenesis of asthma, which is expected to become a new target for the treatment of asthma. This review describes the relative researches on IL-35.

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Available abstract

Bronchial asthma (asthma) is a chronic inflammatory airway disease involved in many cytokines, the mechanism may be related with the imbalance of Th1/Th2 cells or the abnormalities of CD4+CD25+T cells, Th17/IL-17 and so on. Interleukin-35 (IL-35) is a newly discovered cytokine, which is closely related to the immune function of Th17/IL-17 and Tregs. IL-35 may be involved in the pathogenesis of asthma, which is expected to become a new target for the treatment of asthma. This review describes the relative researches on IL-35.

Key concepts: Medicine, Asthma, Pathogenesis, Immunology, Mechanism (biology), Cytokine, Immune system, Disease

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