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Accelerated Wound Healing by ]Recombinant Human Basic Fibroblast Growth Factor in Healing-impaired Animal Models

Soo-Hyung Kang, Tae‐Young Oh, Hyun Jin Cho, Byoung-Ok Ahn, Won Bae Kim

Abstract

The stimulatory effect of recombinant human basic fibroblast growth factor (bFGF) on wound healing was evaluated in healing-impaired animal models. Full-thickness wounds were made in prednisolone-treated mice, streptozotocin (STZ)-induced diabetic rats and mitomycin C (MMC)-treated rats. Saline or bFGF at a dose of 1, 5, or per wound was applied to the open wound once a day for three to five days. The degree of wound healing was assessed using wound size and histological parameters such as degree of epidermal and dermal regeneration. Local application of bFGF accelerated wound closure significantly in a dose-dependent manner in all healing-impaired wounds (p, or of bFGF-treated wounds when compared to saline-treated wounds (p

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Key concepts: Wound healing, Medicine, Basic fibroblast growth factor, Saline, Streptozotocin, Epidermal growth factor, Regeneration (biology), Growth factor