Experiment of inhibitive effect of Artemether on colorectal cancer growth and angiogenesis in BALB/c mice

4002 Purpose: To explore the inhibitive effect of Artemether on colorectal cancer growth and angiogenesis in tumor bearing BALB/c mice. Methods:Forty-eight (24 male and 24 female) BALB/c mice that were subcutaneously implanted with CT-26 colorectal cell (2×106) were divided into 6 groups; each group contained 8 mice. They were low dose group (33.3 mg/kg; oral); middle dose group (50 mg/kg; oral); high dose group (66.6 mg/kg; oral); middle dose plus ferralia (50 mg/kg+1.5 mg/kg; oral); positive control group DDP (5 mg/kg; ip) and blank control normal saline (oral). Microvascular density (MVD) was observed and countered under the microscopy by immunohistochemistry. Results: Inhibitive rates of Artemether by oral administration at low, middle, and high dosages were 42.3%, 51.4%, and 52.0%, respectively, and had significant difference inhibitive effects on colorectal cancer growth (P =0.007, P =0.006, P =0.024 respectively). Combination ferralia and Artemether synergenic the inhibitive effect on tumor bearing mice. MVD in different therapy groups was significantly lower than that in normal saline control group (P