2008•Zhongguo jiceng yiyaoRequires access

Significance and detection of levels of IL-8,TNF-α in serum of patients with aplastic anemia

Gui‐Zhen Yang

Abstract

Objective To investigate the significance of levels of IL-8,TNF-α in serum of patients with aplastic anemia(AA).Methods Serum levels of IL-8 and TNF-α in 45 patients and 30 normal controls were measured by enzyme linked immunosorbent assay.Results The serum levels of IL-8,TNF-α increased significantly in AA and acute AA(AAA)group than in the control group(P＜0.05),there was no statistical significance between chronic AA(CAA)group and the control group(P＜0.05),and the levels in AAA group were much higher than in CAA group(P＜0.05).The serum level of IL-8 was positively related to TNF-αin AA group(r=0.682,P＜0.05).Conclusion There are immunological disorders in patients with AA and the overproduction of IL-8,TNF-α might be involved in the immunopathogenesis of AA,AAA. Key words: Anemia,aplastic; Interleukin-8; Tumor necrosis factor-α

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Key concepts: Aplastic anemia, Medicine, Tumor necrosis factor alpha, Clinical significance, Statistical significance, Internal medicine, Tumor necrosis factor α, Anemia