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2004•Shanxi Yike Daxue xuebaoRequires access

Detection of interlerkin-8 and interferon-α levels in peripheral blood of patients with aplastic anemia

LI Ru-ying

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Abstract

Objective To explor the immunological status of aplastic anemia (AA) and the role of interleukin-8 (IL-8) and interferon-α(IFN-α) in the pathogenesis of AA. Methods Serum levels of IL-8 and IFN-α in 50 patients and 30 normal controls were measured by sandwith enzyme linked immunosorbent assay. Results The levels of IL-8 and IFN-α increased significantly in AA, acute AA (AAA) and chronic AA (CAA) patients than in normal controls (P0.05 or P0.01), and the IL-8 and IFN-α levels in AAA group were much higher than those in CAA group (P0.01). The serum level of IL-8 was positively related to IFN-α in AA group (r=0.703,P0.01). Conclusion There are immunological disorders in patients with AA and the overproduction of IL-8 and IFN-α might be involved in the immunopathogenesis of AA.

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Objective To explor the immunological status of aplastic anemia (AA) and the role of interleukin-8 (IL-8) and interferon-α(IFN-α) in the pathogenesis of AA. Methods Serum levels of IL-8 and IFN-α in 50 patients and 30 normal controls were measured by sandwith enzyme linked immunosorbent assay. Results The levels of IL-8 and IFN-α increased significantly in AA, acute AA (AAA) and chronic AA (CAA) patients than in normal controls (P0.05 or P0.01), and the IL-8 and IFN-α levels in AAA group were much higher than those in CAA group (P0.01). The serum level of IL-8 was positively related to IFN-α in AA group (r=0.703,P0.01). Conclusion There are immunological disorders in patients with AA and the overproduction of IL-8 and IFN-α might be involved in the immunopathogenesis of AA.

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Available abstract

Objective To explor the immunological status of aplastic anemia (AA) and the role of interleukin-8 (IL-8) and interferon-α(IFN-α) in the pathogenesis of AA. Methods Serum levels of IL-8 and IFN-α in 50 patients and 30 normal controls were measured by sandwith enzyme linked immunosorbent assay. Results The levels of IL-8 and IFN-α increased significantly in AA, acute AA (AAA) and chronic AA (CAA) patients than in normal controls (P0.05 or P0.01), and the IL-8 and IFN-α levels in AAA group were much higher than those in CAA group (P0.01). The serum level of IL-8 was positively related to IFN-α in AA group (r=0.703,P0.01). Conclusion There are immunological disorders in patients with AA and the overproduction of IL-8 and IFN-α might be involved in the immunopathogenesis of AA.

Key concepts: Aplastic anemia, Pathogenesis, Immunology, Medicine, Interferon, Interferon γ, Peripheral blood, Anemia

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Detection of interlerkin-8 and interferon-α levels in peripheral blood of patients with aplastic anemia — Research Paper | ScholarLens