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[Detection of interleukin-8 level in peripheral blood of patients with aplastic anemia].

Xiaowen Tang, Yueshuai Zhang, Jiayi Shao

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Abstract

OBJECTIVE: To investigate the role of interleukin-8 in the pathogenesis of aplastic anemia (AA) and its correlation with clinical status. METHODS: Serum level of IL-8 in 24 AA patients and 20 normal controls was measured by sandwich enzyme linked immunosorbent assay(ELISA). RESULTS: The levels of IL-8 were increased significantly(P < 0.05) in AA patients than in normal controls, and the IL-8 levels in severe AA group were much higher than those in chronic AA group (P < 0.05). Serum IL-8 in AA patients with infection were elevated significantly(P < 0.005). CONCLUSION: IL-8 may have a potential role in the pathogenesis of AA and determination of serum IL-8 may be helpful for evaluation of severity and infectious complication of AA.

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What this paper is about

OBJECTIVE: To investigate the role of interleukin-8 in the pathogenesis of aplastic anemia (AA) and its correlation with clinical status. METHODS: Serum level of IL-8 in 24 AA patients and 20 normal controls was measured by sandwich enzyme linked immunosorbent assay(ELISA). RESULTS: The levels of IL-8 were increased significantly(P < 0.05) in AA patients than in normal controls, and the IL-8 levels in severe AA group were much higher than those in chronic AA group (P < 0.05). Serum IL-8 in AA patients with infection were elevated significantly(P < 0.005). CONCLUSION: IL-8 may have a potential role in the pathogenesis of AA and determination of serum IL-8 may be helpful for evaluation of severity and infectious complication of AA.

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Available abstract

OBJECTIVE: To investigate the role of interleukin-8 in the pathogenesis of aplastic anemia (AA) and its correlation with clinical status. METHODS: Serum level of IL-8 in 24 AA patients and 20 normal controls was measured by sandwich enzyme linked immunosorbent assay(ELISA). RESULTS: The levels of IL-8 were increased significantly(P < 0.05) in AA patients than in normal controls, and the IL-8 levels in severe AA group were much higher than those in chronic AA group (P < 0.05). Serum IL-8 in AA patients with infection were elevated significantly(P < 0.005). CONCLUSION: IL-8 may have a potential role in the pathogenesis of AA and determination of serum IL-8 may be helpful for evaluation of severity and infectious complication of AA.

Key concepts: Aplastic anemia, Pathogenesis, Medicine, Gastroenterology, Immunology, Internal medicine, Peripheral blood, Anemia

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[Detection of interleukin-8 level in peripheral blood of patients with aplastic anemia]. — Research Paper | ScholarLens