蔡任军, 谢志斌
Abstract
目的探讨前列素E1在幽门螺旋杆菌(HP)阳性十二指肠溃疡(DU)中促进粘膜愈合的疗效和药理学基础.方法1 00例十二指肠溃疡患者(HP阳性)随机分为两组(n=50),PGE组在传统的三联疗法的基础上,联用前列腺素E1(1 00ug ivdrip qd),对照组仅以三联方案治疗,两组疗程共4周.观察治疗后各组的疗效、消化内镜(溃疡愈合)、HP转阴率.结果PGE组的疗效和溃疡愈合明显好于对照组(P＜0.05),但HP转阴率无统计学意义.结论前列腺素E1能促进十二指肠溃疡的愈合,可能与表皮生长因子等因素有关.
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目的探讨前列素E1在幽门螺旋杆菌(HP)阳性十二指肠溃疡(DU)中促进粘膜愈合的疗效和药理学基础.方法1 00例十二指肠溃疡患者(HP阳性)随机分为两组(n=50),PGE组在传统的三联疗法的基础上,联用前列腺素E1(1 00ug ivdrip qd),对照组仅以三联方案治疗,两组疗程共4周.观察治疗后各组的疗效、消化内镜(溃疡愈合)、HP转阴率.结果PGE组的疗效和溃疡愈合明显好于对照组(P＜0.05),但HP转阴率无统计学意义.结论前列腺素E1能促进十二指肠溃疡的愈合,可能与表皮生长因子等因素有关.
Key concepts: Helicobacter pylori, Medicine, Gastroenterology, Duodenal ulcer, Internal medicine