Analysis of effect of dexmedetomidine on neonatal digestive tract malformation

Objective To investigate the anesthetic effect of dexmedetomidine for neonatal digestive tract malformation. Methods 69 cases of neonatal digestive tract malformation were randomly divided into control group (34 cases) and observation group (35 cases). Remifentanil and dexmedetomidine were used for anesthesia in the two groups respectively, and the hemodynamic changes before and after anesthesia were compared, as well as the effects of postoperative sedation and analgesia. Results The FLACC scores of the observation group at 2 h, 4 h, 6 h, and 24 h after operation were (2.93±1.82) points, (2.33±1.23) points, (1.60±0.62) points, and (1.27±0.52) points, respectively, which were all significantly lower than those of the control group (P<0.05). The Ramsay score at 1 hour after operation in the observation group was (3.36±2.36) points, which was significantly higher than that in the control group [(1.55±0.92) points] (P<0.05). The HR, SBP, and DBP values of the two groups at T1 and T2 were significantly lower than those at T0, and the decrease range in the control group was more significant (P<0.05); the HR, SBP, and DBP values of the two groups at T3 were higher than those at T1 and T2, but still lower than those at T0; the HR, SBP and DBP values of the observation group at T3 respectively were (146.45±5.53) times/min, (67.55±11.51) mmHg, and (41.41±8.24) mmHg, which were significantly higher than those of the control group [(137.14±5.36) times/min, (61.33±10.93) mmHg, (37.26±6.59) mmHg] (P<0.05). Conclusion The use of dexmedetomidine in neonatal digestive tract malformation anesthesia can maintain the stability of hemodynamics, with good analgesia and sedation effect, good resuscitation quality, and few adverse reactions. Key words: Dexmedetomidine; Neonatal digestive tract malformation; Anesthesia; Recovery quality