Effect of dexmedetomidine on reviving period of general anesthesia in thyroid surgery patients

Objective To explore the effect of dexmedetomidine on reviving period of general anesthesia in thyroid surgery patients. Methods A total of 80 patients undergoing thyroid surgery were selected as the subjects.These patients were randomly divided into two groups according to the random table method, 40 cases in each group.The patients in the observation group were given intravenous drip of dexmedetomidine before anesthesia induction, and those in the control group were given intravenous drip of saline.After that, the two groups were given the same method of anesthesia induction.Recovery of the patients, biochemical indicators[including systolic blood pressure(SBP), diastolic blood pressure(DBP), heart rate(HR), oxygen saturation(SpO2)], sedation and analgesia effects, and the incidence of adverse reactions in the two groups were compared. Results The eye opening recovery time, extubation time, spontaneous breathing time and time for orientation recovery in the observation group were (11.24±1.31)min, (8.67±0.78)min, (6.36±0.43)min and (14.39±1.56)min, respectively, which were shorter than those in the control group[(15.57±2.63)min, (10.42±1.12)min, (8.54±0.65)min and (17.24±2.33)min], the differences were statistically significant(t=9.320, 8.109, 17.691, 6.428, all P<0.05). The SBP levels in the observation group at T1 and T2 were (124.69±10.25)mmHg and (105.54±12.87)mmHg, respectively, which were lower than those in the control group[(138.72±13.84)mmHg and (135.25±13.63)mmHg]; DBP at T2 and T3 in the observation group were (71.53±8.95)mmHg and (76.21±7.34)mmHg, respectively, which were lower than those in the control group[(80.45±10.75)mmHg and (80.29±10.39)mmHg]; HR at T2 in the observation group was (65.18±5.75)times, which was lower than (79.84±8.42) in the control group; and all the above differences were statistically significant(t=5.512, 10.024, 4.033, 2.028, 9.094, all P<0.05). The sedation score, pains score in the observation group were (2.89±0.54)points, (1.42±0.34)points, respectively, which were better than those in the control group[(1.02±0.27)points and (3.71±1.12)points], the differences were statistically significant(t=19.589, 12.374, all P<0.05). The incidence rate of adverse reactions in the observation group was 7.50%, which was lower than 35.00% in the control group, and the difference was statistically significant(χ2=9.038, P<0.05). Conclusion For patients given general anesthesia for thyroid surgery, pre-injection of dexmedetomidine can significantly reduce the stress response in patients during recovery period, and has no impact on the patients' awaking and extubation; besides, it has high safety, and can improve the patients' comfort during recovery, thus serve as an ideal drug for the control of restlessness; therefore, it is of significant value to be popularized in clinical application. Key words: Dexmedetomidine; Thyroid surgery; Anesthesia, general; Recovery period