Comparative study of Dexmedetomidine application at the different time during anesthesia induction in elderly patients

Objective To analyze the influence of Dexmedetomidine application at the different time during anesthesia induction in elderly patients on haemodynamics and anesthetic effect. Methods 120 cases of patients with senile gastrointestinal operation from May 2012 to May 2014 in Yinzhou People's Hospital of Ningbo City were selected, they were divided into group Ⅰ, group Ⅱ, group Ⅲ, group Ⅳ, with 30 patients in each group, and 0.9% sodium chloride solution, before induction of Dexmedetomidine, induction of Dexmedetomidine, after induction of Dexmedetomidine were given respectively. The changes of SBP, DBP, MAP, HR in patients before anesthesia(T0), before induction(T1),before intubation(T2), 5 min after intubation(T3), 10 min after intubation(T4) were compared. The RSS score of anesthetic effects before medication, 5 min after medication, 10 min after medication were compared. The adverse reaction of patients were observed. Results At T0, the differences of SBP, DBP and MAP in the four groups were not statistically significant(P 0.05); at T1, T2, the SBP, DBP and MAP reduced(P 0.05), significantly in group Ⅰ; at T3, T4, the SBP, DBP and MAP increased(P 0.05), significantly in group Ⅰ. After Dexmedetomidine application, HR significantly reduced in group Ⅱ, Ⅲ, Ⅳ(P 0.05), significantly in group Ⅱ. The RSS scores in group Ⅱ, Ⅲ, Ⅳ at 5 min after medication, 10 min after medication were higher than those in group Ⅰ; and the RSS score in group Ⅱ was higher than those in group Ⅲ, Ⅳ, the differences were statistically significant(P 0.05). The incidence of adverse event in group Ⅱ was lower than the other three groups, the difference was statistically significant(P 0.05). Conclusion Dexmedetomidine application before induction can effectively stabilize hemodynamics, increase the depth of sedation and reduce the incidence of adverse events. It is worthy of popularizing in clinical anesthesia.