Investigation on Human Immunodeficiency Virus Infections in Different Types of Voluntary Blood Donors in Shenzhen

Objective To explore suitable strategy for blood donation safety under human immunodeficiency virus (HIV) infection new situation.Methods From January 2008 to December 2012,a total of 438 123 voluntary unpaid blood donors in Shenzhen Blood Station were included in this study.According to the definition of classification of blood donors in Whole blood and component donor selection requirements (GB 18467-2011),all the donors were classified into 3 groups:regular voluntary blood donors group (n =87 460),unfixed voluntary blood donors group (n =67 812),and primary voluntary blood donors group (n=282 851).Their blood samples were screened by enzyme-linked immunosorbent assay (ELISA) test and confirmed by Western blotting (WB) test.The distribution and variation trend of their HIV infection rates were analyzed and compared.Results The HIV infection rates of regular voluntary blood donors group from 2008 to 2012 were 0.0,0.0,17.1,10.5 and 9.8 per 100 000,respectively.Total HIV infection rate was 8.0 per 100 000.Regular voluntary blood donors were in a stable state of low prevalence (x2 =1.664,P＞0.05).HIV infection rates of unfixed voluntary blood donors group were 25.0,32.1,60.0,69.6 and 57.4 per 100 000,respectively.The total rate was 50.1 per 100 000.Unfixed voluntary blood donors were in a stable state of high prevalence (x2 =2.606,P＞0.05).HIV infection rates of primary voluntary blood donors group were 15.6,14.3,42.3,62.7 and 67.4 per 100 000,respectively.The total rate was 42.8 per 100 000.HIV infection trends of primary voluntary blood donors was stable and low before 2009,but gradually increased from 2010(x2=30.327,P＜0.01).HIV infection rates of unfixed voluntary blood donors group was the highest (50.1 per 100 000),then HIV infection rates of primary voluntary blood donors group was the second highest (42.8 per 100 000) among these three group.But,there was no statistical difference between them (x2 =0.67,P＞ 0.05).HIV infection rate of regular voluntary blood donors group was significantly lower than unfixed blood donors group or primary blood donors group(x2 =25.69,23.38,P ＜0.01).Conclusions Under the new HIV infection situation of Shenzhen blood donors,that it has not been ensured blood safety by increasing the number of regular voluntary blood donors.Many methods should be accepted for blood safety,for example,using nucleic acid test (NAT) with high sensitivity,strengthening health education of donors,attaching importance to health assessment and recruitment of collective blood donors. Key words: Blood donors;  Volunteers;  Human immunodeficiency virus