The clinical significance of determination of serum low density lipoprotein cholesterol in patients with hepatocir-rhosis

Objective To study the changes of serum low density lipoprotein cholesterol(LDL-C) and clinical significance in patients with hepatocirrhosis. Methods The serum LDL- C contents in groups from 3 573 cases hepatocirrhosis and 168 cases controls were determined. The relationship between serum LDL-C and the factors of prognosis、grades of liver fuction、some complications etc. in hepatocirrhosis patients were analyzed. Results The serum LDL- C contents in hepatocirrhosis group[(1.67±0.94)mmol/L]was significantly lower than that in control group(2.02±0.67)mmol/L](t= 4.67,P<0.01).The serum LDL- C contents in death[(1.30± 1.11mmol/L),the grade of liver function Child- pugh B[(1.74±0.92)mmol/L],the grade of liver function Childpugh C[(1.28±0.97)mmol/L],complicate upper gastrointestinal bleeding[(1.33±0.84)mmol/L],not complicate primary hepatic carcinoma[(1.54±0.82)mmol/L]were significantly lower than that in survival[(1.73±0.90)mmol/ L](t= 9.45,P< 0.01),the grade of liver function Child- pugh A[(2.04±0.76)mmol/L](q= 11.55,P< 0.01),the grade of liver function Child- pugh A[(2.04±0.76)mmol/L](q= 29.25,P< 0.01) and B[(1.74± 0.92)mmol/L](q= 17.71,P< 0.01),not complicate upper gastrointestinal bleeding[(1.76±0.95) mmol/L](t = 11.12,P< 0.01),complicate primary hepatic carcinoma groups[(1.93±1.10)mmol/L](t= 12.02,P< 0.01) with hepatocirrhosis,respectively.significant negative correlation was shown between serum LDL- C contents and liver function grades in patients with hepatocirrhosis(r=- 0.43,P< 0.01). Conclusion The serum LDLC contents was obviously decreased in hepatocirrhosis, and it is closely correlated to the factors of prognosis, grades of liver fuction, whether complicated upper gastrointestinal bleeding and primary hepatic carcinoma, etc. Key words: Liver cirrhosis; Low density lipoprotein cholesterol