Relationship between levels of homocysteine and serum uric acid and stability of carotid atherosclerotic plaque in young patients with cerebral infarction

Objective To investigate the relationship between levels of homocysteine （ Hcy ） and serum uric acid（ UA） and stability of carotid atherosclerotic plaque in young patients with cerebral infarction .Methods 150 cases of cerebral infarction in young patients carried the carotid ultrasonography were divided into the non -plaque group （ n=37）,stable plaque group（n=52） and unstable plaque group（n=61） according to the results.The levels of Hcy and UA in the three groups of patients were detected and analyzed statistically .Results The stable plaque group′s Hcy and UA levels were （15.92 ±2.52）μmol/L and （294.85 ±25.52）μmol/L,which were significantly higher than those of the non-plaque group（t=7.33,6.89,all P〈0.05）;The unstable plaque group′s Hcy and UA levels were （23.17 ±3.82 ）μmol/L and （ 388.57 ±26.61 ）μmol/L, which were significantly higher than those of the the non-plaque group and stable plaque group（t=9.82,10.02,6.90,7.12,all P〈0.05）.Conclusion There is a close correlation between the stability of carotid artery plaque and the levels of Hcy and UA . Key words: Brain infarction; Cysteine; Uric acid; Atherosclerosis carotid