2008•Zhongguo jiceng yiyaoRequires access

The expression of VEGF and PCNA in papillary thyroid carcinoma

Hao-tian Li, Hai-jing Li

Abstract

Objective To investigate the expression of vascular endothial growth faetor(VEGF) proliferating cell nudear antigen(PCNA) and their biological significance was studied in papillary thyroid carcinoma and normal thyroid tissues. Methods Immuohistochemismy S-P technique was used to examine the expression of VEGF and PCNA in specimens of 58 papillary thyroid carcinoma and 19 normal thyroid tissues. Results The positive rates of VEGF and PCNA in papillary thyroid were higher than those in normal thyroid tissues( P＜0.01 ), and a positive correlation between these two expressions existed in papillary thyroid carcinoma. Conclusion VEGF and PCNA could be regarded as parameters to evaluate the biological behavior and they might be the indices for juvant diagnosis and evaluation of papillary thyroid cancer. Key words: Endothial growth factors; Proliferating cell nudear antigen; Papillary neoplasms

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Key concepts: Proliferating cell nuclear antigen, Medicine, Thyroid, Thyroid carcinoma, VEGF receptors, Pathology, Thyroid cancer, Papillary thyroid cancer