Comparison of clinical efficacy between two kinds of comprehensive therapy for refractory lacrimal duct obstruction

Objective To compare the clinical efficacy between two kinds of comprehensive therapy for the treament of refractory lacrimal duct obstruction. Methods The clinical data of 96 eyes of 72 cases with refractory lacrimal duct obstruction from Jan.2017 to Mar.2018 in this hospital were analyzed retrospectively. In trial group, 48 eyes, were treated with cyclosporine A eye drops after lacrimal passage laser recanclization and intubation, and the control group, 48 eyes, were treated with tobramycin dexamethasone eye ointment. The lacrimal passage stent was retained for 3 months and followed up for 6 months after extubation. Results At the end of follow-up, the cure rate of trial group was 83.33%(40/48), the improvement rate was 12.50%(6/48), and the ineffective rate was 4.17%(2/48). The cure rate of control group was 66.67%(32/48), the improvement rate was 20.83%(10/48) and the ineffective rate was 12.50% (6/48). The total effective rate of the trial group was 95.83% (46 /48), which was better than that of the control group (87.50%, 42/48). The difference was statistically significant(χ2=2.136, P=0.001). Conclusion On the basis of operation, application of cyclosporine A eye drops are more effective than tobramycin dexamethasone eye ointment in the treatment of refractory lacrimal passage obstruction. Key words: Obstruction, lacrimal passage, refractory; Laser, lacrimal passage; Catheterization; Eye drops, cyclosporine A; Eye ointment, tobramycin dexamethasone