2012•Guoji yiyao weisheng daobaoRequires access
Expressions and clinical significance of P14 and P16 in cervical carcinoma
Tao Jiang, Tingting Wu, Dan Beverly Fu, Xiaoge Chen, Meiling Wu
Open publisher page 2 citations
Abstract
Objective To explore the expressions of P14 and P16 in cervical carcinoma tissue and its relationship with clinical pathological-parameters.Methods Expressions of P14 protein and P16 in 56 cases' squamous cervical arcinoma tissue,20 cases' CIN Ⅲ tissue and 30 cases' normal cervical tissue were detected with S-P immunochemistry technology.Results The positive expression rates of P14 and P16 proteins were significantly lower in normal cervical tissue than in the CIN Ⅲ and squamous cervical carcinoma( P＜ 0.05 ).The expression of P14 in squamous cervical carcinoma related to tumor infiltrate deepness,pathological stage and lymph node metastasis ( P ＜ 0.05 ) but not related to clinical stage,age,tumor size and cancer embolus( P＞ 0.05 ).The expression of P16 in squamous cervical carcinoma related to pathological stage and lymph node metastasis ( P ＜ 0.05 ) but not related to clinical stage,age,tumor size, tumor infiltrate deepness and cancer embolus ( P ＞ 0.05 ).Conclusions P14 and P16 expess highly in CIN and cervical carcinoma,which has value in the diagnosis and prognostic valuation of cervical carcinoma.Consequently,both of them can be used as biomarkers for the screening and diagnosis of cervical carcinoma.
Key words:
Cervical Carcinoma; P14 protein; P16 protein; Immunohistochemistry