Midazolam versus propofol in gastroscopy

Objective To investigate the safety and efficacy of midazolam and propofol in gastroscopy. Methods 234 patients scheduled for painless gastroscopy were divided into group A ( 123patients ) and group B ( 111 patients ). Group A received intravenous midazolam of 0.02 ～ 0.03mg · kg-1and group B received propofol of 1.2mg · kg-1 prior to endoscopy examination. 120 control subjects were group C. Results The onset time was ( 2.5 ± 1.6 ) mim in group A and ( 1.8 ± 1.2 ) mim in group B; and the awakening time was( 10.2 ± 2.1 ) mim in group A and ( 8.7 ± 2.6 )mim in group B. Rates of nausea, agitation, and dry cough were 8.13％, 25.20％, and 2.44％ in group A and 0％, 4.50％, 0％,and 2.70％ in group B, which were markedly lower than those in group C ( 85.00％, 47.50％, and 24.16％,respectively; P＜ 0.05 ) SBP, DBP, HR, and SPO2 did not differ significantly in groups A and B after the procedure ( P＞ 0.05 ). SBP, DBP, and HR, as compared with their baselines, decreased more significantly in group B than in group A ( P＜ 0.05 ) during the procedure, while SPO2 did not change significantly ( P ＞ 0.05 ). Conclusions Propofol has a better analgetic effect and shorter onset and awakening time; midazolam is simple in use and causes no significant changes in respiratory and circulatory systems. Either propofol or midazolam is safe and effective in gastroscopy and has fewer adverse reactions. Key words: Midazolam;  Propofol;  Painless gastroscopy