2010•国际外科学杂志Requires access
PTEN and thyroid tumor
Feng-yan Yin, Detao Yin
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Abstract
A tumor suppressor gene at 10q23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers and sporadic tumor. In this paper, we reviewed the construction and function of PTEN, and the mechanism of activation in cancer especially in thyroid carcinoma.
Key words:
Phosphatase and tensin homomlogy deleted on ten; Thyroid cancer; Tumor suppressor