Advancement in the Study of PTEN and Its Relation with Breast Cancer
Yan Song
Abstract
Yan Song
Abstract
PTEN discovered in 1997 is a tumor suppressor gene with dual specificity phosphatase activity.PTEN gene brings into its lipid and protein phosphatase activity through PIP3/Akt,MAPK/ERK,FAK pathways.PTEN gene is closely related with breast cancers.This paper reviewed about the recent developments in the study of PTEN and its relation with breast cancer.
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PTEN discovered in 1997 is a tumor suppressor gene with dual specificity phosphatase activity.PTEN gene brings into its lipid and protein phosphatase activity through PIP3/Akt,MAPK/ERK,FAK pathways.PTEN gene is closely related with breast cancers.This paper reviewed about the recent developments in the study of PTEN and its relation with breast cancer.
Key concepts: PTEN, Phosphatase, Protein kinase B, Breast cancer, Cancer research, Tumor suppressor gene, Suppressor, MAPK/ERK pathway