The Study of Tumor Suppressor Gene PTEN in the Carcinoma of Urinary System

PTEN(phosphatase and tensin homolog deleted on chromosome ten)is phosphatase specificity and can inhibit oncogenesis.The mutation and loss of PTEN is the oncogenesis basis of all kinds of tumor,including urinary system tumor.Studies show that mutation and loss of PTEN,which can lead to the dysfunction of tumor suppress,induced oncogenesis of renal cell carcinoma,bladder carcinoma and prostatic carcinoma,revealling that PTEN can inhibit tumorigenesis of urnary system.But the detail of the mutation and loss of PTEN and how PTEN inhibit tumorigensis are still unclear,further study is warranted.