2016•Chin J Diagnostics(Electronic Edition)Requires access
The expression and significance of cytokeratin 14 and E-cadherin in patients with esophageal squamous cell carcinoma
Jing Liu, Yifeng Zhang, Bao Zhang, Shanshan Cui, Liyan Sun, Rujian Zhang
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Abstract
Objective
To explore the expression and clinical significance of cytokeratin 14(CK14) and E-cadherin in patients with the esophageal squamous cell carcinoma(ESCC).
Methods
One hundred and sixty cases of esophageal paraffin blocks with 130 cases of human ESCC tissues (observation group) and 30 cases of normal esophageal tissues (control group) were collected.For observation group, according to histopathological differentiation degree, TNM clinical stage, tumor infiltration depth, 104 cases were divided to high differentiation group, while the rest 26 cases as poorly differentiated group; 51 cases were sort to Ⅰ, Ⅱ stage and 79 cases as Ⅲ, Ⅳ stage; fiber membrane infiltration were discovered in 57 cases, while 73 cases with no fiber membrane infiltration.The CK14 and E-cadherin expression were detected by the immunohistochemical staining method.The expression characteristics and the mutual relations of CK14 and E-cadherin in esophageal squamous carcinoma tissues were analyzed and compared.
Results
Expression of CK14: (1)the expression intensity of CK14 in observation group was 165.47±19.15, while it was 141.14±14.59 in control group, there was a significant difference between the two groups (t=3.29, P 1.76).
Conclusions
The higher expression of CK14 and the lower expression of E-cadherin are related to the occurrence and progress of esophageal squamous cell carcinomas.CK14 and E-cadherin can be independent diagnosis index of esophageal squamous cell carcinomas.CK14 and E-cadherin may become the new therapeutic targets for esophageal squamous carcinoma.
Key words:
Esophaged neoplasms; Carcinoma, squamous cell; Keratin-14; E-cadherin