2013•Jiangsu Medical JournalRequires access
The expression and clinical significance of CD44v6 and E-cadherin in the esophageal squamous cell carcinoma
Wang Shukui
Open publisher page 1 citations
Abstract
Objective To investigate the expression and clinical significance of CD44v6 and E-cadherin in the esophageal squamous cell carcinoma.Methods With immunohistochemistry,the expressions of CD44v6 and E-cadherin were detected in 48 esophageal squamous carcinoma tissues(group A),23 erosive esophagitis tissues(group B) and 24 normal esophagus tissues(group C).The relationship of the expressions of CD44v6 and E-cadherin and clinicopathological characteristics of esophageal squamous cell carcinoma were analyzed.Results Compared to groups of B and C,the expression of CD44v6 was higher,but that of E-cadherin was lower,in group A(P0.05).The expressions of CD44v6 and E-cadherin were closely related to the depth of invasion and the status of lymph node metastasis of esophageal squamous cell carcinoma(P0.05).The expression level of CD44v6 was negatively correlated with that of E-cadherin in group A(r=-0.580,P0.05).Conclusion Combined detection of CD44v6 and E-cadherin in diseased tissues is hopeful as the adjutant indicators in screening and predicting the prognosis of esophageal squamous cell carcinoma.