Prophylactic effect of tropisetron on postoperative vomiting after laparoscopic cholecystecystectomy

Objective To observe the prophylactic effect of tropisetron on postoperative vomitting after laparoscopic cholecystectomy. Methods One hundred and fifty patients were divided into 5 groups randomly,respectively treated with saline 5 ml（ group A）,tropisetron 2 mg 10 minutes before anesthesia induction（ group B）,tropisetron 2 mg ﹢ dexamethasone 10 mg 10 minutes before anesthesia induction（ group C）,tropisetron 5 mg 10 minutes before anesthesia induction（ group D）,tropisetron 2 mg after LC（ group E）. Make a different record about the degree of PONV on patients 6 and 24 h after operation. Results The incidence of PONV on the other 4 groups decrease obviously within 24 h,comparing with group A;and the incidence of group C and D was lower than that in group B（ P﹤0. 05 ）. In addition,there was no significant difference between group C and D or between group B and E. Conclusions The prophylactic effect of tropisetron 2 mg﹢dexamethasone 10 mg on PONV is a kind of economic,effective,safe and application of popularization of anti-nausea method. Key words: Laparoscopic cholecystectomy;  Postoperative nausea and vomiting;  Tropisetron