Influence of tropisetron combined with dexamethasone on postoperative nausea and vomiting after gynecologic laparoscopic surgery

Objective To asudy the effects of tropisetron combined with dexamethasone on postoperative nausea and vomiting(PONV) after gynecologic laparoscopic surgery. Methods Ninety gynecologic patients undergoing laparoscopic surgery were randomly divided into three groups with 30 cases each.The patients in group T were given tropisetron 4 mg,those in group TD tropisetron 4 mg and dexamethasone 5 mg,and those in group C normal saline 5 ml as the controls at 10 minutes before induction of general anesthesia.PONV within 24 hours was recorded and OAAS sedation scores were evaluated. Results Compared with group C,the incidence and intensity of postoperative 24-h PONV were significantly lower in groups of T and TD (P0.05 and P0.01). The intensity of nausea,incidence and intensity of vomiting in 24 h after operation were lower in group TD than those in group T(P0.05).Conclusion Tropisetron combined with dexamethasone is better than tropisetron alone in reducing PONV after gynecologic laparoscopic surgery.