Mechanisms underlying the antifungal resistance in Candida albicans

Various antifungal agents have been used in the treatment of Candida albicans infection.As a common opportunistic pathogen,Candida albicans has shown an increasing antifungal resistance year by year,which are believed to result from the collaborative interaction between multiple complex mechanisms,including changes in ergosterol biosynthesis,enhancement of drug efflux,alterations in the molar ratio of phospholipid to sterol in cell membrane,glucan in cell wall and in DNA synthesis in cell nuclei,as well as biofilm formation.Active measures should be taken to prevent and control Candida albicans infection. Key words: Candida albicans;  Antifungal agents;  Drug resistance